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Brain Modulation Laboratory

The Brain Modulation Laboratory, directed by R. Mark Richardson, MD, PhD, is a human systems neuroscience lab that studies brain electrophysiology, cognition, imaging, and histopathology in patients undergoing surgery for epilepsy and movement disorders. The overall goal of the lab’s work is to facilitate the optimization of brain modulation therapies and the discovery of novel neurobiological targets, by filling gaps in our understanding of human brain function critical for helping patients.

Areas of study include:

Basal Ganglia-Cortical Dynamics in Human Behavior
Intraoperatively, task-based, simultaneously recorded cortical ECoG and subcortical MER/LFP data is collected to study interactions between the cortex and basal ganglia that code for specific components of motor action. 

Cortical Effects of DBS Studied with Magnetoelcephalography 
One of the few research programs in the world using magnetoencephalography (MEG) to study the effects of DBS on cortical function. 

Brain Stimulation for Epilepsy
A data management and analysis pipeline was created to study recordings generated in epilepsy patients implanted with the Responsive Neurostimulation System (RNS). Similarly, the effects of chronic stimulation are investigated in a NHP with idiopathic epilepsy, implanted with a sensing enabled DBS device (RC+S).

GABAegic Innervation of Human Epileptic Hippocampus
The lab has built a large brain bank of en bloc hippocampal specimens resected during epilepsy surgery. Current studies are focused on defining bouton-level alterations in GABAerigic innervation of dentate granule cell neurons.

[See Intraoperative Electrode Localization Tool.]

For more detailed information on the Brain Modulation Laboratory, please visit brainmodulationlab.org.

We are indebted to our epilepsy and movement disorder patients who allow the use of their clinical data to benefit neuroscience and to potentially help future patients.