Ian F. Pollack, MD

A. Leland Albright Distinguished Professor
Vice Chair, Academic Affairs
Chief, Pediatric Neurosurgery
Co-Director, Neurosurgical Oncology


Ian Pollack

Contact

412-692-5881

Biography

Ian Pollack, MD, is co-director of the Brain Tumor Program at the University of Pittsburgh Cancer Institute, Chief of Pediatric Neurosurgery at UPMC Children’s Hospital of Pittsburgh, and A. Leland Albright Professor of Neurosurgery at the University of Pittsburgh School of Medicine.

Prior to joining the faculty of the Department of Neurological Surgery at the University of Pittsburgh in 1992, he was awarded the 1991 Van Wagenen Traveling Fellowship, which afforded him a year of subspecialty training in the Department of Neurosurgery at the Hospital for Sick Children in Toronto, the Neuro-Oncology Laboratory of the University of Lausanne in Switzerland, and the Laboratory of Tumor Biology of the University of Uppsala in Sweden.

Dr. Pollack graduated magna cum laude from Emory University in 1980, where he earned a BS degree in chemistry. He received his medical degree from the Johns Hopkins University School of Medicine in 1984, then completed a surgical internship and neurosurgical residency at the University of Pittsburgh School of Medicine. He also was a research fellow in neuropathology and neurobiology during some of that time.

Pollack has published more than 340 papers in refereed journals, numerous book chapters and invited papers, and has edited two books on childhood brain tumors. He is co-editor of the book Principles and Practice of Pediatric Neurosurgery—currently in its third edition—and an accompanying atlas Operative Techniques In Pediatric Neurosurgery.

He is currently a principal investigator on numerous NIH grants focusing on novel therapies for brain tumors and evaluating molecular markers of tumor prognosis. Dr. Pollack was named vice chairman of academic affairs for the department in July of 2008.

He also chaired the Children’s Oncology Group CNS Tumor Committee from 1999-2009, and co-chaired the National Cancer Institute Brain Malignancy Steering Committee between 2010 and 2017.


Specialized Areas of Interest

Pediatric neurosurgery; pediatric neuro-oncology; craniofacial surgery; congenital spinal abnormalities; brain tumor clinical trials.

Board Certifications

American Board of Neurological Surgery
American Board of Pediatric Neurosurgery

Hospital Privileges

UPMC Children’s Hospital of Pittsburgh
UPMC Magee-Womens Hospital
UPMC Presbyterian

Professional Organization Membership

Academy of Neurological Surgeons
Alpha Omega Alpha
American Association for the Advancement of Science
American Association for Cancer Research
American Association of Neurological Surgeons (AANS)
American College of Surgeons
American Society for Pediatric Neurosurgery 
American Society for Clinical Investigation
Association of American Physicians 
Children’s Oncology Group
Congress of Neurological Surgeons (CNS)
Johns Hopkins Medical and Surgical Society
Joint Section on Tumors (AANS/CNS)
Phi Beta Kappa
Society of Neurological Surgeons
Society for Neuro-Oncology
Society of Surgical Oncology

Education & Training

BS, Chemistry, Emory University, Magna cum Laude, 1980
MD, Johns Hopkins University School of Medicine, 1984
Residency, University of Pittsburgh, 1991
Fellowship, University of Pittsburgh, 1990
Fellowship, Hospital for Sick Children, 1991
Fellowship, University of Lausanne, 1991
Fellowship, University of Uppsala, 1992

Honors & Awards

  • Albert Nelson Marquis Lifetime Achievement Award, 2018
  • Best Doctors in Pittsburgh, Pittsburgh Magazine, 2012-18
  • Castle Connolly’s America’s Top Doctors, 2002-18
  • Who’s Who in America (Marquis), 2005-18
  • Who’s Who in the World (Marquis), 2008-18
  • Castle Connolly’s America’s Top Cancer Doctors, 2005-18
  • Certificate of Appreciation, National Cancer Institute, 2017
  • Children’s Brain Tumor Foundation, Award for Scientific Excellence, 2016
  • Columbia Softball Charity Award, American Association of Neurological Surgeons Annual Meeting, 2016 
  • Winn Prize, Society of Neurological Surgeons, 2015 
  • Van Wagenen Lecturer, American Association of Neurological Surgeons Annual Meeting, 2014

Selected Publications

Premkumar DD, Jane EP, Thambireddy S, Sutera P, Cavaleri J, Pollack IF. Mitochondrial dysfunction, RAD51 and Ku80 proteolysis promotes apoptotic effects of Dinaciclib in Bcl-xL silenced cells. Molec Carcinogenesis 57:469-482, 2018.

Müller S, Agnihotri S, Shoger KE, Myers MI, Smith N, Chaparala S, Villanueva CR, Chattopadhyay A, Lee AV, Butterfield LH, Diaz A, Okada H, Pollack IF, Kohanbash G. Peptide vaccine immunotherapy biomarkers and response patterns in pediatric gliomas. JCI Insight 3(7):e98791, 2018.

Jakacki RI, Cohen KJ, Buxton A, Krailo MD, Burger PC, Rosenblum MK, Brat DJ, Hamilton RL, Eckel SP, Zhou T, Lavey RS, Pollack IF. Phase 2 study of concurrent radiotherapy and temozolomide followed by temozolomide and lomustine in the treatment of children with high-grade glioma: A report of the Children’s Oncology Group ACNS0423 studyNeuro-Oncology 18:1442-1450, 2016.

Pollack IF, Jakacki RI, Butterfield LH, Hamilton RL, Panigrahy A, Normolle DP, Connelly AK, Dibridge S, Mason G, Whiteside TL, Okada H. Immune responses and outcome after vaccination with glioma-associated antigen peptides and poly-ICLC in a pilot study for pediatric recurrent low-grade gliomas. Neuro-Oncology 18:1157-1168, 2016.

Jane EP, Premkumar DR, Cavaleri JM, Sutera PA, Rajasekar T, Pollack I. Dinaciclib, a CDK inhibitor promotes proteasomal degradation of Mcl-1 and enhances ABT-737 mediated cell death in malignant human glioma cell lines. J Pharmacol Exp Ther 356(2):354-65, 2015.

Jakacki RI, Burger P, Kocak M, Boyett J, Goldwein J, Mehta M, Packer RJ, Tarbell N, Pollack IF. Outcome and prognostic factors for children with supratentorial primitive neuroectodermal tumors (SPNET) treated with carboplatin during craniospinal radiotherapy: A report from the Children’s Oncology Group. Pediatr Blood Cancer 62:776-783, 2015.

Pollack IF, Jakacki RI, Butterfield LH, Hamilton RL, Panigrahy A, Potter DM, Connelly AK, Dibridge SA, Whiteside TL, Okada H. Antigen-specific immune responses and clinical outcome after vaccination with glioma-associated antigen peptides and Polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in children with newly diagnosed malignant brainstem and nonbrainstem gliomas. J Clin Oncol 32:2050-2058, 2014. 

Ater JL, Zhou T, Holmes E, Mazewski CM, Booth TN, Freyer DR, Lazarus KH, Packer RJ, Prados M, Sposto R,Vezina G, Wisoff JH, Pollack IF. Randomized study of two chemotherapy regimens for treatment of low grade glioma in young children: A Children’s Oncology Group Study. J Clin Oncol 30:2641-2647, 2012.

Pollack IF, Hamilton RL, Sobol RW, Nikiforova MN, Lyons-Weiler MA, LaFramboise WA, Burger PC, Brat DJ, Rosenblum MK, Holmes EJ, Zhou T, Jakacki RI. IDH1 mutations are common in malignant gliomas arising in adolescents: A report from the Children’s Oncology Group. Child’s Nerv Syst 27:87-94, 2011.

Jane EP, Premkumar D, Pollack IF. Bortezomib sensitizes malignant human glioma cells to TRAIL mediated by inhibition of the NF-ĸB signaling pathway. Molecular Cancer Ther 10:198-208, 2011.

Pollack IF, Stewart CF, Kocak M, Young-Poussaint T, Bronsicer A, Banerjee A, Douglas J, Kun LE, Boyett JM, Geyer JR. A phase II study of gefitinib and irradiation in children with newly diagnosed brain stem gliomas: A report from the Pediatric Brain Tumor Consortium. Neuro-Oncology 13:290-297, 2011.

Thaker NG, McDonald PR, Zhang F, Shun TY, Lewen MD, Pollack IF, Lazo JS. Identification of survival genes in human glioblastoma cells using siRNA screening. Molec Pharm 76:1246-1255, 2009.

A complete list of Dr. Pollack's publications can be reviewed through the National Library of Medicine's publication database.

Research Activities

Dr. Pollack’s group has continued an ongoing focus on molecular characterization of childhood brain tumors as a foundation for defining prognostic subsets and groups amenable to molecularly targeted therapy. During the last year, Dr. Pollack’s group collaborations with the Children’s Brain Tumor Tissue Consortium enabled them to access a large cohort of childhood high-grade gliomas, which will be subjected to integrated genomic analysis to follow up on their previous observations that molecular alterations in the Akt signaling pathway, such as PTEN deletions and PIK3CA and PTEN mutations, have an adverse association with outcome. Targeted sequencing data will be combined with immunohistochemical analysis and whole genome and RNA sequencing to define the genomic spectrum of this subset of tumors in comparison to other subgroups of pediatric high-grade gliomas. In parallel, they are evaluating strategies to inhibit PI3K/Akt signaling in preclinical models that recapitulate the Akt-activating alterations noted above.

Dr. Pollack’s group has also continued NIH funded activities that focus on immunotherapy for pediatric brain tumors. During the last year, they have applied RNA sequencing of peripheral blood mononuclear cells in their low-grade glioma cohort to characterize gene expression patterns associated with favorable response to vaccine therapy. They also identified expression patterns that were associated with lack of response. Future efforts will be directed at examining whether these response-associated expression patterns are observed in high-grade glioma and ependymoma cohorts, or are unique to low-grade gliomas. Accrual continues on ongoing clinical trials for recurrent low-grade gliomas and ependymomas, and newly diagnosed high-grade gliomas treated with radiation alone.

Media Appearances

Immunotherapy
Fall 2014
UPMC Cancer Center 2014 Annual Report

Glioma: Pilot Trial Shows Peptide Vaccine Active in Pediatric Patients
May 25, 2012
Oncology Times

First-of-its-kind Study of Peptide Vaccine by Pittsburgh Researchers Shows Evidence of Immunological Response in Children with Gliomas
April 4, 2012
HealthCanal.com

Study Suggests Vaccine May Help Kids With Brain Cancer
April 3, 2012
U.S. News and World Report Health Day

Study Suggests Vaccine May Help Kids With Brain Cancer
April 3, 2012
Health.com

Study Suggests Vaccine May Help Kids With Brain Cancer
April 3, 2012
MSN Health

Peptide vaccine shows evidence of immunological, clinical activity in children with gliomas
April 3, 2012
MedicalExpress.com

Brain Tumor Vaccine for Children
April 2, 2012
WTAJ-TV (Johnstown)

Teen Has New Lease On Life After Brain Tumor Removal 
July 22, 2009
WTAE TV-4 (Pittsburgh) Evening News

Study finds clue to deadly childhood brain cancers
February 7, 2002
Pittsburgh Post-Gazette

UPMC On Topic Videos

Brain Care Institute: Expertise
Dr. Pollack talks about managing many of the unusual types of brain tumors.

Brain Care Institute: A Top-Notch Institution
Dr. Pollack talks about the advantages afforded by working at Children's Hospital of Pittsburgh.

Brain Care Institute: A Rewarding Experience
Dr. Pollack talks about the experiences that give him a great sense of satisfaction in his work.